In vivo anti-inflammatory, antipyretic, analgesic activity and in vitro anti-proliferative activity of aqueous methanolic extract of Euphorbia granulata Forssk

Abstract Background Naturally occurring substances of plant origin have long been used in folk medicine for curing various ailments including fever, pain, and inflammation etc. After careful evaluation on scientific bases, a large number those provides cheaper alternative to currently synthetic or semi-synthetic agents. Thus, with an aim discovering treatment such ailments, current study was carried out. Euphorbia granulata Forssk. had as therapeutic agent against morbid conditions, e.g., anthelmintic, snake bite, scorpion sting, purgative, diuretic, blood purifying medicine. The purpose the determine extended use based upon evaluation, explore potential its anti-proliferative, analgesic, antipyretic, anti-inflammatory activities while using aqueous methanol extract whole plant. Results In vivo performed female rats specie Rattus norvegicus weighing (100–150 g). Anti-inflammatory activity calculated carrageenan induced paw edema. Analgesic both central peripheral assessed by Eddy’s hot plate method acetic acid-induced writhing model, respectively. antipyretic appraised brewer’s yeast suspension, injected under nape neck, body temperature measured digital thermometer. strengths experiments were 50 mg, 100 200 mg/kg (diluted normal saline) administered through intra-peritoneal route. MTT assay estimate vitro anti-proliferative potential. For this assay, serial dilution μg/ml highest concentration. results demonstrated that at dose strength mg/kg, showed significant ( p * < 0.05) anti-inflammatory, activities. case however, no > observed up strength. Conclusion It can be concluded (whole plant) shown anti-pyretic animal model. Therefore it candidate, algesia, pyrexia, pathological origin. However, did not demonstrate any anti-proliferation doses study.